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As an overmethylator, one may exhibit symptoms of elevated dopamine and serotonin. Symptoms of overmethylation may include paranoia, high anxiety, auditor hallucinations. A targeted nutrient management protocol developed by Dr Walsh, identified an individuals biotype based on labs plus a history. With that information, one may be better informed to their specific needs for supplementation. It is advisable that one avoid taking these supplements if they do not have a proper diagnosis, as they tend to lower serotonin and dopamine function. Supplementing with these vitamins can be very problematic when take by persons with depression and schizophrenia caused by undermethylation or copper and toxic overload biotypes.