Copper overload is an oxidative stress state that can lead to depression, anxiety, bipolar disorder, insomnia and post-partum depression.
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Dr Walsh refers to metallothioneins, selenium and glutathione the Three Musketeers of antioxidant protection. His research shows that high copper depressives show little response to antidepressants. They tend to do with antioxidants, copper lowering supplements and an improved digestive system.