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Supplements for Undermethylation

Undermethylation is a widespread biochemical anomaly affecting DNA in all cellular structures. Those who experience undermethylation can present a variety of symptoms such as chronic depression, OCD behaviors, oppositional attitudes in children, and may even have conditions like autism or schizoaffective disorder. It’s noteworthy that not all undermethylated individuals manifest these specific symptoms. Some may exhibit increased libido, intense religiosity, marked competitiveness in academics or sports, or come from achievement-oriented families. Additional characteristics may encompass seasonal allergies, a predisposition to a lean musculature, dietary protein deficiency, or a preference for vegetarianism. Due to the typical reduction in serotonin and dopamine activity in undermethylated individuals, particular supplements like SAMe, methionine, and specific B vitamins can be beneficial. Adherents to the Walsh Methodology in treating mood disorders frequently caution against the consumption of folates and niacin owing to their possible detrimental influence on serotonin and dopamine levels. These supplements, although essential for conditions such as elevated homocysteine or overmethylation, are omitted from the recommendations herein.



Best Overmethylation

Niacinamide 180 Capsules


Best Undermethylation

SAMe 200 mg 60 Capsules


Source Naturals

SAMe 400mg 30 Tablets


Copper Overload Supplements

Vitamin B8 – Inositol 650 mg 100 Capsules


Immunity / Infections

Vitamin D – D-10,000 60 caps


Liquids, Powders, Chewables

Vitamin D Liquid 1 oz


Immunity / Infections

Vitamin D3 10,000 IU 120 Capsules


Immunity / Infections

Vitamin D3 With K2 Liquid 1 oz


Best Copper Overload

Zinc Picolinate 50mg


Symptoms associated with undermethylation depression may include Autism, chronic depression, schizophrenia, bipolar disorder, OCD obsessive-compulsive disorder, seasonal depression and etc. Other common characteristics include seasonal allergies, perfectionism, religiosity, strong will and competitiveness.