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If your physician follows the Walsh Protocol then here you will find the supplements that are most suitable for undermethylators.

Because undermethylators are low in serotonin and dopamine activity, according to Walsh, folic acid, niacin, DMAE or choline are not recommended, as they lower the activity of these neurotransmitters.


Allergy Research Group

B6 Pyridoxine + P5P 60 cap 275 mg


Allergy Research Group

L-Methionine 500 mg 100 Capsules


Copper Overload

D3 10,000 with K2 60 gels



Biotin-8 60 Capsules





Symptoms associated with undermethylation include obsessive-compulsive tendencies, oppositional-defiant disorder or seasonal depression. Other common characteristics include seasonal allergies, perfectionism, strong will and competitiveness. If undermethylated, you may be advised to correct the problem using SAMe, methionine, calcium and magnesium, among other supplements offered here. *According to Dr Walsh, "Although most undermethylated patients thrive on folates, supplements of folates must be avoided for patients whose problems are dominated by low activity at serotonin receptors.  Folic acid, folinic acid, and methylfolate all reduce serotonin/dopamine neurotransmission by an epigenetic mechanism, and this effect overwhelms the folate benefits of improved methylation and serotonin synthesis."